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De:
Luiz Meira <luizmeira@aleph.com.br>
Data: Qua Abr 21, 1999 7:43
pm
Assunto: [gen-ocidio] DNA alimentar para o feto
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Aí gente... a coisa pega!
Imaginem os DNA da soja transgênica nos lípides
culinários, nas pastas matinais, na panificação. Imaginem
os resíduos das enzimas
utilizadas nos alimentos industrializados. . . tadinhos dos ninhos que
virão por aí...
><> Luiz Roberto Salvatori Meira ><> Equilíbrio
Alimentar
<>< http://www.aleph.com.br/~luizmeira
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De:
Herve LE MEUR <Herve.LEMEUR@math.u-psud.fr>
Data: Qua Abr 21, 1999 6:32
am
Assunto: alimentary
Para: gentech@gen.free.de
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Hi all,
I've just found on Medline the following abstract. By and large, it
claims to have proved that traces of ingested DNA (not modified food OK)
can be found in the nuclei (!) of the cells of various organs of the new-born
animals when the mother has been fed with this plasmid (once agin OK : it's
not GMO).
I think this article could be quoted as relevant in the topic of alimentary
risks.
DO I misunderstand ?
HLM
Mol Gen Genet 1998 Oct;259(6):569-76
On the fate of orally ingested foreign DNA in mice: chromosomal association and
placental transmission to the fetus.
Schubbert R, Hohlweg U, Renz D, Doerfler W
Institute of Genetics, University of Cologne, Koeln, Germany.
We have previously shown that, when administered orally to mice, bacteriophage
M13 DNA, as a paradigm foreign DNA without
homology to the mouse genome, can persist in fragmented form in the
gastrointestinal tract, penetrate the intestinal wall, and reach the
nuclei of leukocytes, spleen and liver cells. Similar results were obtained
when
a plasmid containing the gene for the green fluorescent
protein (pEGFP-C1) was fed to mice. In spleen, the foreign DNA was detected in
covalent linkage to DNA with a high degree of
homology to mouse genes, perhaps pseudogenes, or to authentic E. coli DNA. We
have now extended these studies to the offspring of mice
that were fed regularly during pregnancy with a daily dose of 50 microg of M13
or pEGFP-C1 DNA. Using the polymerase chain reaction
(PCR) or the fluorescent in situ hybridization (FISH) method, foreign DNA,
orally ingested by pregnant mice, can be discovered in various
organs of fetuses and of newborn animals. The M13 DNA fragments have a length
of
about 830 bp. In various organs of the mouse fetus,
clusters of cells contain foreign DNA as revealed by FISH. The foreign DNA is
invariably located in the nuclei. We have never found all
cells of the fetus to be transgenic for the foreign DNA. This distribution
pattern argues for a transplacental pathway rather than for
germline transmission which might be expected only after long-time feeding
regimens. In rare cells of three different fetuses, whose
mothers have been fed with M 13 DNA during gestation, the foreign DNA was
detected by FISH in association with both chromatids. Is
maternally ingested foreign DNA a potential mutagen for the developing fetus?
PMID: 9819049, UI: 99034358
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